Disruption of the NMD pathway in cancer cells. A step towards defeating cancer
Production of proteins in each cell can be encumbered with potential errors. There are many mechanisms in living organisms that minimize the formation of defective, undesirable proteins. One of these security mechanisms (the NMD pathway) controls the correctness of the messenger RNA (mRNA): breakdown of the abnormal mRNA occurs when a STOP codon is detected. The NMD mechanism prevents potential problems caused by defective proteins.
