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Disruption of the NMD pathway in cancer cells. A step towards defeating cancer

Cancer cells
Blocking the pathway for removing mRNA with nonsense codons, or NMD, in the proteins of cancer cells is an opportunity to create a non-invasive and extremely effective cancer therapy. Researchers from Gdańsk University of Technology are working on such solution together with the University of Gdańsk, as part of the Fahrenheit Union of Universities.

Production of proteins in each cell can be encumbered with potential errors. There are many mechanisms in living organisms that minimize the formation of defective, undesirable proteins. One of these security mechanisms (the NMD pathway) controls the correctness of the messenger RNA (mRNA): breakdown of the abnormal mRNA occurs when a STOP codon is detected. The NMD mechanism prevents potential problems caused by defective proteins.

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